# Clinical Catalyst Radar for Biotech (`scrapemint/clinical-catalyst-pipeline`) Actor

For each biotech company, correlates clinical pipeline progress (ClinicalTrials.gov) and research momentum (PubMed) with open-market insider buying (SEC Form 4), scores convergence 0 to 100, and tiers companies catalyst, clinical lead, insider lead, or watch. An advancing asset plus insiders buying.

- **URL**: https://apify.com/scrapemint/clinical-catalyst-pipeline.md
- **Developed by:** [Ken M](https://apify.com/scrapemint) (community)
- **Categories:** Business, News
- **Stats:** 2 total users, 1 monthly users, 100.0% runs succeeded, 0 bookmarks
- **User rating**: No ratings yet

## Pricing

Pay per usage

This Actor is paid per platform usage. The Actor is free to use, and you only pay for the Apify platform usage, which gets cheaper the higher subscription plan you have.

Learn more: https://docs.apify.com/platform/actors/running/actors-in-store#pay-per-usage

## What's an Apify Actor?

Actors are a software tools running on the Apify platform, for all kinds of web data extraction and automation use cases.
In Batch mode, an Actor accepts a well-defined JSON input, performs an action which can take anything from a few seconds to a few hours,
and optionally produces a well-defined JSON output, datasets with results, or files in key-value store.
In Standby mode, an Actor provides a web server which can be used as a website, API, or an MCP server.
Actors are written with capital "A".

## How to integrate an Actor?

If asked about integration, you help developers integrate Actors into their projects.
You adapt to their stack and deliver integrations that are safe, well-documented, and production-ready.
The best way to integrate Actors is as follows.

In JavaScript/TypeScript projects, use official [JavaScript/TypeScript client](https://docs.apify.com/api/client/js.md):

```bash
npm install apify-client
```

In Python projects, use official [Python client library](https://docs.apify.com/api/client/python.md):

```bash
pip install apify-client
```

In shell scripts, use [Apify CLI](https://docs.apify.com/cli/docs.md):

````bash
# MacOS / Linux
curl -fsSL https://apify.com/install-cli.sh | bash
# Windows
irm https://apify.com/install-cli.ps1 | iex
```bash

In AI frameworks, you might use the [Apify MCP server](https://docs.apify.com/platform/integrations/mcp.md).

If your project is in a different language, use the [REST API](https://docs.apify.com/api/v2.md).

For usage examples, see the [API](#api) section below.

For more details, see Apify documentation as [Markdown index](https://docs.apify.com/llms.txt) and [Markdown full-text](https://docs.apify.com/llms-full.txt).


# README

## Clinical Catalyst Radar for Biotech

Find the biotech name where **an asset is advancing through the clinic and management is buying the stock at the same time** before the rest of the market connects the two.

For each company you pass, this pipeline joins three independent signals:

1. **Clinical progress** — ClinicalTrials.gov studies sponsored by the company: trial phase, recruiting/active status, enrollment, recent updates, posted results.
2. **Research momentum** — PubMed papers behind the program and their citation weight.
3. **Insider conviction** — SEC Form 4 open-market purchases (code P) by company insiders.

A trial advancing is public knowledge that can take quarters to reprice. Insider buying is informed but tells you nothing about *why*. The edge is the **overlap**: a Phase 2/3 asset moving **and** insiders putting their own cash in. This pipeline scores that convergence 0–100 and tiers each company.

### Input

```json
{
  "companies": ["Moderna | MRNA", "CRISPR Therapeutics | CRSP", "BioNTech | BNTX"],
  "insiderLookbackDays": 90,
  "clinicalSinceDays": 540,
  "trialsPerCompany": 25,
  "papersPerCompany": 20,
  "includeInsider": true,
  "minScore": 0
}
````

Each company is `Company Name | TICKER`. The **name** drives the ClinicalTrials.gov sponsor match and the PubMed search; the **ticker** drives the Form 4 insider lookup. Trials are attributed to a company only when its name matches the study's lead sponsor or a collaborator (corporate suffixes like *Inc.*, *Therapeutics*, *Pharma* are ignored), so the clinical signal is the company's own pipeline, not a keyword soup.

### Output

One row per company:

```json
{
  "ticker": "MRNA",
  "company": "Moderna",
  "tier": "catalyst",
  "convergenceScore": 71,
  "scoreBreakdown": { "clinical": 34, "research": 22, "insider": 15 },
  "clinical": {
    "trialCount": 9,
    "topPhase": "Phase 3",
    "advancingCount": 4,
    "recentlyUpdatedCount": 5,
    "withResultsCount": 2,
    "topTrials": [{ "nctId": "NCT0...", "phase": "Phase 3", "status": "ACTIVE_NOT_RECRUITING", "sponsor": "ModernaTX, Inc.", "enrollment": 1200, "lastUpdate": "2026-05-12", "url": "https://clinicaltrials.gov/study/NCT0..." }]
  },
  "research": {
    "paperCount": 14,
    "recentPaperCount": 9,
    "totalCitations": 640,
    "highImpactCount": 3,
    "topPapers": [{ "pmid": "...", "year": 2025, "citations": 210, "title": "...", "url": "https://pubmed.ncbi.nlm.nih.gov/..." }]
  },
  "insider": {
    "buyCount": 3, "sellCount": 0, "buyValueUsd": 480000, "netValueUsd": 480000, "netBuying": true,
    "lastBuyDate": "2026-05-28",
    "topBuys": [{ "insider": "Jane Doe", "role": "Director", "shares": 5000, "price": 32.1, "valueUsd": 160500, "date": "2026-05-28" }]
  },
  "scoredAt": "2026-06-10T..."
}
```

#### Tiers

- **catalyst** — a Phase 2+ asset is actively advancing **and** insiders are net buyers, with a convergence score ≥ 55. The thesis is fully formed. The first catalyst per run is free.
- **clinical\_lead** — a strong, advancing pipeline with research weight, but insiders are quiet.
- **insider\_lead** — insiders are buying, but the clinical pipeline is early or thin.
- **watch** — limited signal on both sides.

#### Scoring (0–100)

- **Clinical (0–45):** highest trial phase (Phase 3/4 weighted near-market), count of actively advancing trials, recent updates, posted results.
- **Research (0–30):** recent (last 2 years) publication volume, total citations, count of above-expected-impact papers.
- **Insider (0–25):** open-market buy value, number of buys, net buying vs selling.

### Pricing and cost

Pay per company, by tier: **watch $0.05**, **single-signal lead $0.10**, **catalyst $0.16**. The first catalyst per run is free so you can validate output.

This pipeline calls two of our own actors as children, and **each child also bills you for its own per-row usage**: `pubmed-clinical-trials-intelligence` (one charge per trial/paper row, called once per company) and `sec-form4-insider-tracker` (one charge per insider transaction, called once per run). Both children run on public government JSON APIs (NCBI E-utilities, ClinicalTrials.gov v2, SEC EDGAR) with no browser and no residential proxy, so the underlying compute is small and the per-company price stays above it.

### Notes

- **No API keys.** Everything runs on public government endpoints.
- **Attribution is per company.** The clinical/research child is called once per company so trials and papers are matched to the right name, never guessed from a shared query.
- **Graceful degradation.** If one company's clinical lookup or the insider stage hits a transient block, that signal is skipped and the rest of the run still scores and returns.

# Actor input Schema

## `companies` (type: `array`):

One entry per company, formatted "Company Name | TICKER". The name drives the ClinicalTrials.gov sponsor match and PubMed search; the ticker drives the Form 4 insider lookup. Example: \["Moderna | MRNA", "BioNTech | BNTX", "CRISPR Therapeutics | CRSP"].

## `insiderLookbackDays` (type: `integer`):

How far back to read SEC Form 4 open-market buys and sells.

## `clinicalSinceDays` (type: `integer`):

Only count ClinicalTrials.gov studies and PubMed papers updated within this window. Defaults to 540 days (18 months) so the score reflects current momentum, not history.

## `trialsPerCompany` (type: `integer`):

How many ClinicalTrials.gov studies to pull per company for the clinical-progress signal.

## `papersPerCompany` (type: `integer`):

How many PubMed papers to pull per company for the research-momentum signal.

## `includeInsider` (type: `boolean`):

Pull SEC Form 4 open-market buys/sells. Turn off to score clinical + research only.

## `minScore` (type: `integer`):

Drop companies scoring below this convergence score (0 to 100). 0 keeps everything with any data.

## `proxyConfiguration` (type: `object`):

Proxy passed through to the SEC Form 4 child. The clinical/research child uses government APIs directly and needs no proxy.

## Actor input object example

```json
{
  "companies": [
    "Moderna | MRNA",
    "CRISPR Therapeutics | CRSP",
    "BioNTech | BNTX"
  ],
  "insiderLookbackDays": 90,
  "clinicalSinceDays": 540,
  "trialsPerCompany": 25,
  "papersPerCompany": 20,
  "includeInsider": true,
  "minScore": 0,
  "proxyConfiguration": {
    "useApifyProxy": true
  }
}
```

# API

You can run this Actor programmatically using our API. Below are code examples in JavaScript, Python, and CLI, as well as the OpenAPI specification and MCP server setup.

## JavaScript example

```javascript
import { ApifyClient } from 'apify-client';

// Initialize the ApifyClient with your Apify API token
// Replace the '<YOUR_API_TOKEN>' with your token
const client = new ApifyClient({
    token: '<YOUR_API_TOKEN>',
});

// Prepare Actor input
const input = {
    "companies": [
        "Moderna | MRNA",
        "CRISPR Therapeutics | CRSP",
        "BioNTech | BNTX"
    ]
};

// Run the Actor and wait for it to finish
const run = await client.actor("scrapemint/clinical-catalyst-pipeline").call(input);

// Fetch and print Actor results from the run's dataset (if any)
console.log('Results from dataset');
console.log(`💾 Check your data here: https://console.apify.com/storage/datasets/${run.defaultDatasetId}`);
const { items } = await client.dataset(run.defaultDatasetId).listItems();
items.forEach((item) => {
    console.dir(item);
});

// 📚 Want to learn more 📖? Go to → https://docs.apify.com/api/client/js/docs

```

## Python example

```python
from apify_client import ApifyClient

# Initialize the ApifyClient with your Apify API token
# Replace '<YOUR_API_TOKEN>' with your token.
client = ApifyClient("<YOUR_API_TOKEN>")

# Prepare the Actor input
run_input = { "companies": [
        "Moderna | MRNA",
        "CRISPR Therapeutics | CRSP",
        "BioNTech | BNTX",
    ] }

# Run the Actor and wait for it to finish
run = client.actor("scrapemint/clinical-catalyst-pipeline").call(run_input=run_input)

# Fetch and print Actor results from the run's dataset (if there are any)
print("💾 Check your data here: https://console.apify.com/storage/datasets/" + run["defaultDatasetId"])
for item in client.dataset(run["defaultDatasetId"]).iterate_items():
    print(item)

# 📚 Want to learn more 📖? Go to → https://docs.apify.com/api/client/python/docs/quick-start

```

## CLI example

```bash
echo '{
  "companies": [
    "Moderna | MRNA",
    "CRISPR Therapeutics | CRSP",
    "BioNTech | BNTX"
  ]
}' |
apify call scrapemint/clinical-catalyst-pipeline --silent --output-dataset

```

## MCP server setup

```json
{
    "mcpServers": {
        "apify": {
            "command": "npx",
            "args": [
                "mcp-remote",
                "https://mcp.apify.com/?tools=scrapemint/clinical-catalyst-pipeline",
                "--header",
                "Authorization: Bearer <YOUR_API_TOKEN>"
            ]
        }
    }
}

```

## OpenAPI specification

```json
{
    "openapi": "3.0.1",
    "info": {
        "title": "Clinical Catalyst Radar for Biotech",
        "description": "For each biotech company, correlates clinical pipeline progress (ClinicalTrials.gov) and research momentum (PubMed) with open-market insider buying (SEC Form 4), scores convergence 0 to 100, and tiers companies catalyst, clinical lead, insider lead, or watch. An advancing asset plus insiders buying.",
        "version": "0.1",
        "x-build-id": "DD7bfO3Pkd7Mu7lti"
    },
    "servers": [
        {
            "url": "https://api.apify.com/v2"
        }
    ],
    "paths": {
        "/acts/scrapemint~clinical-catalyst-pipeline/run-sync-get-dataset-items": {
            "post": {
                "operationId": "run-sync-get-dataset-items-scrapemint-clinical-catalyst-pipeline",
                "x-openai-isConsequential": false,
                "summary": "Executes an Actor, waits for its completion, and returns Actor's dataset items in response.",
                "tags": [
                    "Run Actor"
                ],
                "requestBody": {
                    "required": true,
                    "content": {
                        "application/json": {
                            "schema": {
                                "$ref": "#/components/schemas/inputSchema"
                            }
                        }
                    }
                },
                "parameters": [
                    {
                        "name": "token",
                        "in": "query",
                        "required": true,
                        "schema": {
                            "type": "string"
                        },
                        "description": "Enter your Apify token here"
                    }
                ],
                "responses": {
                    "200": {
                        "description": "OK"
                    }
                }
            }
        },
        "/acts/scrapemint~clinical-catalyst-pipeline/runs": {
            "post": {
                "operationId": "runs-sync-scrapemint-clinical-catalyst-pipeline",
                "x-openai-isConsequential": false,
                "summary": "Executes an Actor and returns information about the initiated run in response.",
                "tags": [
                    "Run Actor"
                ],
                "requestBody": {
                    "required": true,
                    "content": {
                        "application/json": {
                            "schema": {
                                "$ref": "#/components/schemas/inputSchema"
                            }
                        }
                    }
                },
                "parameters": [
                    {
                        "name": "token",
                        "in": "query",
                        "required": true,
                        "schema": {
                            "type": "string"
                        },
                        "description": "Enter your Apify token here"
                    }
                ],
                "responses": {
                    "200": {
                        "description": "OK",
                        "content": {
                            "application/json": {
                                "schema": {
                                    "$ref": "#/components/schemas/runsResponseSchema"
                                }
                            }
                        }
                    }
                }
            }
        },
        "/acts/scrapemint~clinical-catalyst-pipeline/run-sync": {
            "post": {
                "operationId": "run-sync-scrapemint-clinical-catalyst-pipeline",
                "x-openai-isConsequential": false,
                "summary": "Executes an Actor, waits for completion, and returns the OUTPUT from Key-value store in response.",
                "tags": [
                    "Run Actor"
                ],
                "requestBody": {
                    "required": true,
                    "content": {
                        "application/json": {
                            "schema": {
                                "$ref": "#/components/schemas/inputSchema"
                            }
                        }
                    }
                },
                "parameters": [
                    {
                        "name": "token",
                        "in": "query",
                        "required": true,
                        "schema": {
                            "type": "string"
                        },
                        "description": "Enter your Apify token here"
                    }
                ],
                "responses": {
                    "200": {
                        "description": "OK"
                    }
                }
            }
        }
    },
    "components": {
        "schemas": {
            "inputSchema": {
                "type": "object",
                "required": [
                    "companies"
                ],
                "properties": {
                    "companies": {
                        "title": "Companies",
                        "type": "array",
                        "description": "One entry per company, formatted \"Company Name | TICKER\". The name drives the ClinicalTrials.gov sponsor match and PubMed search; the ticker drives the Form 4 insider lookup. Example: [\"Moderna | MRNA\", \"BioNTech | BNTX\", \"CRISPR Therapeutics | CRSP\"].",
                        "default": [],
                        "items": {
                            "type": "string"
                        }
                    },
                    "insiderLookbackDays": {
                        "title": "Insider lookback (days)",
                        "minimum": 7,
                        "maximum": 365,
                        "type": "integer",
                        "description": "How far back to read SEC Form 4 open-market buys and sells.",
                        "default": 90
                    },
                    "clinicalSinceDays": {
                        "title": "Clinical/research window (days)",
                        "minimum": 30,
                        "maximum": 1825,
                        "type": "integer",
                        "description": "Only count ClinicalTrials.gov studies and PubMed papers updated within this window. Defaults to 540 days (18 months) so the score reflects current momentum, not history.",
                        "default": 540
                    },
                    "trialsPerCompany": {
                        "title": "Trials per company",
                        "minimum": 5,
                        "maximum": 60,
                        "type": "integer",
                        "description": "How many ClinicalTrials.gov studies to pull per company for the clinical-progress signal.",
                        "default": 25
                    },
                    "papersPerCompany": {
                        "title": "Papers per company",
                        "minimum": 5,
                        "maximum": 50,
                        "type": "integer",
                        "description": "How many PubMed papers to pull per company for the research-momentum signal.",
                        "default": 20
                    },
                    "includeInsider": {
                        "title": "Include insider buying",
                        "type": "boolean",
                        "description": "Pull SEC Form 4 open-market buys/sells. Turn off to score clinical + research only.",
                        "default": true
                    },
                    "minScore": {
                        "title": "Minimum score",
                        "minimum": 0,
                        "maximum": 100,
                        "type": "integer",
                        "description": "Drop companies scoring below this convergence score (0 to 100). 0 keeps everything with any data.",
                        "default": 0
                    },
                    "proxyConfiguration": {
                        "title": "Proxy configuration",
                        "type": "object",
                        "description": "Proxy passed through to the SEC Form 4 child. The clinical/research child uses government APIs directly and needs no proxy.",
                        "default": {
                            "useApifyProxy": true
                        }
                    }
                }
            },
            "runsResponseSchema": {
                "type": "object",
                "properties": {
                    "data": {
                        "type": "object",
                        "properties": {
                            "id": {
                                "type": "string"
                            },
                            "actId": {
                                "type": "string"
                            },
                            "userId": {
                                "type": "string"
                            },
                            "startedAt": {
                                "type": "string",
                                "format": "date-time",
                                "example": "2025-01-08T00:00:00.000Z"
                            },
                            "finishedAt": {
                                "type": "string",
                                "format": "date-time",
                                "example": "2025-01-08T00:00:00.000Z"
                            },
                            "status": {
                                "type": "string",
                                "example": "READY"
                            },
                            "meta": {
                                "type": "object",
                                "properties": {
                                    "origin": {
                                        "type": "string",
                                        "example": "API"
                                    },
                                    "userAgent": {
                                        "type": "string"
                                    }
                                }
                            },
                            "stats": {
                                "type": "object",
                                "properties": {
                                    "inputBodyLen": {
                                        "type": "integer",
                                        "example": 2000
                                    },
                                    "rebootCount": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "restartCount": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "resurrectCount": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "computeUnits": {
                                        "type": "integer",
                                        "example": 0
                                    }
                                }
                            },
                            "options": {
                                "type": "object",
                                "properties": {
                                    "build": {
                                        "type": "string",
                                        "example": "latest"
                                    },
                                    "timeoutSecs": {
                                        "type": "integer",
                                        "example": 300
                                    },
                                    "memoryMbytes": {
                                        "type": "integer",
                                        "example": 1024
                                    },
                                    "diskMbytes": {
                                        "type": "integer",
                                        "example": 2048
                                    }
                                }
                            },
                            "buildId": {
                                "type": "string"
                            },
                            "defaultKeyValueStoreId": {
                                "type": "string"
                            },
                            "defaultDatasetId": {
                                "type": "string"
                            },
                            "defaultRequestQueueId": {
                                "type": "string"
                            },
                            "buildNumber": {
                                "type": "string",
                                "example": "1.0.0"
                            },
                            "containerUrl": {
                                "type": "string"
                            },
                            "usage": {
                                "type": "object",
                                "properties": {
                                    "ACTOR_COMPUTE_UNITS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATASET_READS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATASET_WRITES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "KEY_VALUE_STORE_READS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "KEY_VALUE_STORE_WRITES": {
                                        "type": "integer",
                                        "example": 1
                                    },
                                    "KEY_VALUE_STORE_LISTS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "REQUEST_QUEUE_READS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "REQUEST_QUEUE_WRITES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATA_TRANSFER_INTERNAL_GBYTES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATA_TRANSFER_EXTERNAL_GBYTES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "PROXY_RESIDENTIAL_TRANSFER_GBYTES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "PROXY_SERPS": {
                                        "type": "integer",
                                        "example": 0
                                    }
                                }
                            },
                            "usageTotalUsd": {
                                "type": "number",
                                "example": 0.00005
                            },
                            "usageUsd": {
                                "type": "object",
                                "properties": {
                                    "ACTOR_COMPUTE_UNITS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATASET_READS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATASET_WRITES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "KEY_VALUE_STORE_READS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "KEY_VALUE_STORE_WRITES": {
                                        "type": "number",
                                        "example": 0.00005
                                    },
                                    "KEY_VALUE_STORE_LISTS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "REQUEST_QUEUE_READS": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "REQUEST_QUEUE_WRITES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATA_TRANSFER_INTERNAL_GBYTES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "DATA_TRANSFER_EXTERNAL_GBYTES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "PROXY_RESIDENTIAL_TRANSFER_GBYTES": {
                                        "type": "integer",
                                        "example": 0
                                    },
                                    "PROXY_SERPS": {
                                        "type": "integer",
                                        "example": 0
                                    }
                                }
                            }
                        }
                    }
                }
            }
        }
    }
}
```