InterPro Protein Families & Domains Scraper

Scrape protein families, domains, functional sites, GO terms and member-database signatures from InterPro — the EBI resource that classifies proteins into families and predicts the presence of domains and important sites. No API key. No login. Just point it at a type, a search term, or a list of accessions.

InterPro integrates predictive signatures from member databases (Pfam, SMART, CDD, PROSITE, PRINTS, PANTHER and more) into a single classification of over 54,000 entries. This actor turns that into clean, structured JSON ready for annotation pipelines, spreadsheets, or downstream analysis.

Pricing: pay-as-you-go, roughly ~$0.5 per 1,000 entries scraped (plus Apify platform usage). The InterPro REST API is free.

What makes this different from my other biology actors

InterPro answers "what family/domain is this protein and what does it do?" — it is the classification & functional annotation layer. That is a different question from the other scrapers on this account:

Actor	Answers	Layer
InterPro (this one)	Which families, domains & functional sites does a protein contain? GO terms, member DBs	Classification / annotation
UniProt scraper	What is the protein — its sequence, names, function text, features	Sequence / knowledgebase
AlphaFold scraper	What is its 3D structure (predicted model, pLDDT, PDB/CIF)	Structure
Reactome scraper	Which pathways is it in	Pathways
STRING scraper	Which proteins does it interact with	Interaction networks

In short: UniProt gives you the sequence, AlphaFold gives you the structure, and InterPro tells you which families and domains that sequence belongs to. Use them together.

Modes

• entries — browse/filter all InterPro entries, optionally by type (domain, family, site, ...).
• search — free-text query (e.g. "kinase", "zinc finger").
• accessions — resolve an explicit list of InterPro accessions (e.g. IPR000719) to full detail records with GO terms, counters and descriptions.

Input

Field	Type	Description
mode	select	entries (default), search, or accessions.
entryType	select	any (default), family, domain, repeat, site, conserved_site, binding_site, active_site, ptm. Applies to entries and search.
queries	array	Search terms for search mode, e.g. ["kinase", "zinc finger"].
accessions	array	InterPro accession IDs for accessions mode, e.g. ["IPR000719"].
maxItems	integer	Max records to output (default 200, max 5000).

Example input

{
  "mode": "accessions",
  "accessions": ["IPR000719", "IPR011009"],
  "maxItems": 200
}

Output

Each dataset item:

{
  "type": "interpro_entry",
  "accession": "IPR000719",
  "name": "Protein kinase domain",
  "entry_type": "domain",
  "source_database": "interpro",
  "description": "This entry represents the protein kinase domain ...",
  "protein_count": 1949997,
  "structure_count": 8165,
  "taxa_count": 40328,
  "go_terms": [{"id": "GO:0005524", "name": "ATP binding", "category": "molecular_function"}],
  "go_term_count": 2,
  "member_databases": ["profile", "pfam", "smart"],
  "member_db_count": 3,
  "integrated": null,
  "literature_count": 10,
  "url": "https://www.ebi.ac.uk/interpro/entry/InterPro/IPR000719/",
  "source": "interpro",
  "scraped_at": "2026-08-11T00:00:00Z"
}

All fields are nullable. Counters (protein_count, structure_count, taxa_count) and GO terms are richest in accessions mode, which fetches the full entry detail.

Use cases

• Protein annotation — attach family/domain and GO-term context to a list of accessions.
• Functional genomics — enrich gene/protein sets with functional-site classification.
• Domain analysis — pull every domain-type entry and its member-database signatures.
• Bioinformatics pipelines — a keyless, structured feed of InterPro classification for reproducible workflows.

Notes

• Data © EMBL-EBI / InterPro, provided under their terms; this actor is an unofficial client of the public REST API.
• Pagination uses InterPro cursor URLs; large runs page automatically until maxItems.