Biomedical Trial & Literature Evidence Report

Biomedical research, medical affairs, and evidence teams use this Actor to compare ClinicalTrials.gov records with PubMed citation metadata. Input trial-literature watchlists, NCT IDs, conditions, interventions, PubMed queries, and a recurring monitor key. Get source-linked evidence rows, trial-to-literature gap alerts, evidence reports, and research exports from official APIs.

Store Quickstart

{
  "watchlists": [{
    "id": "cancer-immunotherapy",
    "conditions": ["cancer"],
    "interventions": ["immunotherapy"],
    "pubmedQuery": "cancer immunotherapy clinical trial"
  }],
  "searchTerms": ["cancer immunotherapy clinical trial"],
  "fromDate": "2026",
  "sort": "most_recent",
  "maxArticles": 25,
  "runMode": "monitor",
  "monitorKey": "cancer-immunotherapy-evidence",
  "initialRunMode": "emit_backfill",
  "emitRawRows": false,
  "generateReport": true,
  "generateExport": false,
  "maxChargeUsd": 3,
  "dryRun": false
}

The default initialRunMode: "baseline_only" stores the first trial and literature baseline with zero rows and zero charge. An unchanged later run also emits zero rows and zero charge.

Run the next report

• Use OpenAlex Research Intelligence for broader cross-domain publication metadata.

Input examples

Current literature report

{
  "searchTerms": ["GLP-1 obesity"],
  "fromDate": "2025",
  "maxResultsPerQuery": 25,
  "maxArticles": 50,
  "runMode": "audit",
  "emitRawRows": false,
  "generateReport": true,
  "dryRun": false
}

PMID metadata export

{
  "pmids": ["39763750", "39763800"],
  "runMode": "extract",
  "emitRawRows": true,
  "generateReport": false,
  "generateExport": true,
  "dryRun": false
}

New-publication monitor

{
  "searchTerms": ["CAR-T solid tumor"],
  "sort": "most_recent",
  "maxArticles": 100,
  "runMode": "monitor",
  "monitorKey": "car-t-solid-tumor-watch",
  "initialRunMode": "baseline_only",
  "emitRawRows": false,
  "generateReport": true,
  "generateExport": false,
  "dryRun": false
}

The first baseline-only monitor emits no rows. Later runs emit only changed trials, newly observed PMIDs, evidence gaps, and requested reports.

Sample output

{
  "rowType": "literature_update_report",
  "billingEventName": "biomedical-evidence-report",
  "query": {
    "searchTerms": ["cancer immunotherapy"],
    "fromDate": "2026"
  },
  "articleCount": 12,
  "pmids": ["39763750", "39763800"],
  "topJournals": [{"value": "Cancer Research", "count": 3}],
  "summary": "12 PubMed publications matched this literature update.",
  "sourceUrl": "https://pubmed.ncbi.nlm.nih.gov/"
}

Pricing

Event	Price	Emitted when
biomedical-evidence-row	$0.008	A normalized trial or literature evidence row is emitted
evidence-gap-alert	$0.15	A saved monitor observes a source-linked evidence gap
biomedical-evidence-report	$5.00	A trial and literature evidence report is generated
biomedical-evidence-export	$3.00	A normalized evidence export is generated

There is no start charge. Use emitRawRows: false for report-first runs, and maxChargeUsd to cap planned Actor charges.

Source and limits

• Uses official NCBI ESearch and ESummary JSON endpoints; no browser scraping or login is required.
• An optional free NCBI API key increases the documented request allowance. Keyless mode is paced conservatively.
• This Actor exports citation metadata, not article full text or abstracts.
• PubMed records can be incomplete or updated after publication.

Compliance

Outputs support literature research and screening workflows. They are not medical advice, clinical efficacy claims, or a substitute for reviewing the source publication. Keep NCBI attribution and source URLs in downstream reports.