Human CRISPR/Cas9 Research Evidence

A bounded Apify Actor that collects and normalizes public evidence about CRISPR/Cas9 research involving humans from authoritative APIs:

• ClinicalTrials.gov v2 API
• PubMed / NCBI E-utilities

Safety and scope

Research indexing only. This Actor does not provide medical advice, diagnose anyone, recommend treatments, rank clinics, collect patient PII, or generate clinical conclusions. Every record links to its authoritative source. Abstracts, when enabled, are copied from PubMed rather than invented or summarized.

Input

• query: additional research terms; CRISPR/Cas9 and human constraints are always applied.
• sources: clinicaltrials, pubmed, or both.
• maxItems: hard output cap, 1–100.
• fromDate, toDate: optional inclusive YYYY-MM-DD bounds.
• trialStatuses: optional ClinicalTrials.gov statuses such as RECRUITING.
• includePubMedAbstracts: include source abstracts when available.
• ncbiToolEmail: optional NCBI contact metadata; never emitted to output or logs.

Example:

{
  "query": "sickle cell disease",
  "sources": ["clinicaltrials", "pubmed"],
  "maxItems": 20,
  "fromDate": "2022-01-01",
  "trialStatuses": ["RECRUITING", "ACTIVE_NOT_RECRUITING"],
  "includePubMedAbstracts": true
}

Output

One normalized dataset row per study/article, deduplicated by authoritative source ID. Records include source URL, dates, provenance, structured trial or bibliographic fields, and the research-only disclaimer. OUTPUT_SUMMARY records counts, source coverage, and honest limitations.

Local verification

npm ci
npm test
npm run build
apify validate-schema .actor/input_schema.json
apify run --purge --input '{"query":"sickle cell disease","maxItems":6}'

Source and API limits

The Actor uses only fixed HTTPS endpoints on clinicaltrials.gov and eutils.ncbi.nlm.nih.gov, preventing user-controlled URL fetching. Public API availability, indexing lag, and NCBI rate limits can affect coverage. Human relevance must still be checked in each linked primary record.