Clinical Trial & FDA Signal Alerts — Drug, Sponsor & Condition Watch

Get alerted when a new clinical trial appears for your drug, condition, or competitor, when a tracked trial changes status (for example RECRUITING → TERMINATED) or slips its primary completion date, and when an FDA drug recall / enforcement signal hits your watched products or firms — without re-reading ClinicalTrials.gov and openFDA every morning.

Built for pharma/biotech competitive intelligence, medical affairs, investor research, and market analysts. Official public APIs only — no API keys, no login, no proxies.

What you get

Row	Event	Price	When
New trial alert	new-trial-alert	$0.10	A trial matching your watch appears that was not tracked before
Trial status change alert	trial-status-change-alert	$0.08	A tracked trial's overall status or primary completion date changed
FDA signal alert	fda-signal-alert	$0.10	A new or status-changed FDA drug enforcement (recall) report matches your watch
Pipeline watch report	pipeline-watch-report	$5	Opt-in (generateReport: true): one source-linked summary row per run with alerts
Watch export	watch-export-generated	$7	Opt-in (emitExport: true): one export bundle row per run with alerts
Raw record row	raw-record-row	$0.006	Opt-in (emitRawRows: true): every normalized source record

No-change runs are free. The first run saves a baseline and charges nothing (default initialRunMode: "baseline_only"). After that, you are only charged when something actually changed.

Quickstart

1. Define a watch:

{
  "watches": [
    {
      "id": "glp1-obesity-watch",
      "drugs": ["semaglutide", "tirzepatide"],
      "conditions": ["obesity"],
      "sponsors": ["Novo Nordisk", "Eli Lilly"]
    }
  ]
}

2. Run once — the baseline is saved, nothing is charged.
3. Add a daily/weekly Schedule. Each run emits only what changed since the last run: new trials, status flips, completion-date slips, and new FDA recall signals.

Want the current matches immediately (instead of a silent baseline)? Set initialRunMode: "emit_backfill" on the first run.

How watches match

• Within a field, terms are OR — "drugs": ["semaglutide", "tirzepatide"] matches trials with either drug.
• Across fields, conditions are AND (ClinicalTrials.gov) — drugs + conditions + sponsors narrows the trial set. Want "any trial of drug X or any trial by sponsor Y"? Use two watches.
• On openFDA, drugs/keywords match product_description and sponsors match recalling_firm (merged, deduplicated).
• Optional phases (e.g. ["PHASE3"]) and statuses filters apply to trials. Note: a statuses filter can hide status-change alerts for trials that leave the filtered set — leave it empty for termination monitoring.

Inputs

Field	Default	Notes
watches	— (required)	Each needs at least one of drugs, conditions, sponsors, keywords
sources	["trials", "fda"]	ClinicalTrials.gov API v2 + openFDA drug enforcement
monitorKey	my-clinical-trials-fda-watch	Stable key for the persistent monitoring state
initialRunMode	baseline_only	emit_backfill to emit current matches on the first run
generateReport	false	Opt-in $5 report row
emitExport	false	Opt-in $7 export row
emitRawRows	false	Opt-in $0.006 raw rows
maxRecordsPerWatch	50	Per watch and source, max 100
maxChargeUsd	25	Hard budget: the run fails closed before delivering rows that would exceed it

Why not just the free APIs?

ClinicalTrials.gov and openFDA are free — but they answer "what exists right now", not "what changed since I last looked". This actor adds the monitoring layer: normalized records across both sources, persistent per-watch state, new/changed diffing (including RECRUITING → TERMINATED flips and completion-date slips), deduplication, zero-noise scheduled runs that stay free when nothing changed, and a hard maxChargeUsd budget. It also runs on a schedule with webhooks/dataset integrations and works as an AI-agent/MCP tool — no code to host.

Data sources, limits, compliance

• Sources: ClinicalTrials.gov API v2 and openFDA drug enforcement — official public US government APIs, queried directly with no keys.
• Rows summarize public registry/enforcement data for human review; sources can revise or remove records after capture. openFDA data is not a complete list of FDA actions and does not establish causation.
• Not medical, clinical, regulatory, legal, or investment advice. No patient-level data or PHI. See docs/source-compliance.md.

Related actors

• Government Tender & Grants Alert Report — the same free-when-unchanged watch model for public tenders and grants.
• OpenAlex Research Intelligence — new-paper alerts for authors, institutions, and concepts.